Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1997093..1997612 Replicon chromosome
Accession NZ_CP102094
Organism Streptococcus suis strain 12RC1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8MQK4
Locus tag NQZ84_RS09665 Protein ID WP_024383250.1
Coordinates 1997093..1997350 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0M9FLP3
Locus tag NQZ84_RS09670 Protein ID WP_029693536.1
Coordinates 1997352..1997612 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ84_RS09650 (NQZ84_09650) 1993723..1995453 - 1731 WP_257047757.1 hypothetical protein -
NQZ84_RS09655 (NQZ84_09655) 1995656..1996528 - 873 WP_014736465.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NQZ84_RS09660 (NQZ84_09660) 1996549..1997079 - 531 WP_257047753.1 DUF1697 domain-containing protein -
NQZ84_RS09665 (NQZ84_09665) 1997093..1997350 - 258 WP_024383250.1 Txe/YoeB family addiction module toxin Toxin
NQZ84_RS09670 (NQZ84_09670) 1997352..1997612 - 261 WP_029693536.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NQZ84_RS09675 (NQZ84_09675) 1998127..1998582 - 456 WP_044769048.1 8-oxo-dGTP diphosphatase -
NQZ84_RS09680 (NQZ84_09680) 1998586..1998954 - 369 WP_044769046.1 hypothetical protein -
NQZ84_RS09685 (NQZ84_09685) 1998947..1999537 - 591 WP_061845168.1 ribonuclease M5 -
NQZ84_RS09690 (NQZ84_09690) 1999500..2000282 - 783 WP_079397312.1 TatD family hydrolase -
NQZ84_RS09695 (NQZ84_09695) 2000390..2000527 - 138 WP_002939016.1 50S ribosomal protein L34 -
NQZ84_RS09700 (NQZ84_09700) 2000695..2001690 - 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
NQZ84_RS09705 (NQZ84_09705) 2001710..2002522 - 813 WP_024395757.1 YidC/Oxa1 family membrane protein insertase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1995656..2028347 32691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10293.77 Da        Isoelectric Point: 7.3119

>T253186 WP_024383250.1 NZ_CP102094:c1997350-1997093 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADKLYILSL
KDHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9950.29 Da        Isoelectric Point: 5.1255

>AT253186 WP_029693536.1 NZ_CP102094:c1997612-1997352 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8MQK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0M9FLP3

References