253183

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1402788..1403442 Replicon chromosome
Accession NZ_CP102094
Organism Streptococcus suis strain 12RC1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NQZ84_RS06870 Protein ID WP_172107642.1
Coordinates 1403077..1403442 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0Z8BYX8
Locus tag NQZ84_RS06865 Protein ID WP_044670992.1
Coordinates 1402788..1403087 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ84_RS06840 (NQZ84_06840) 1398015..1399016 - 1002 WP_024408714.1 peptidylprolyl isomerase PrsA -
NQZ84_RS06845 (NQZ84_06845) 1399078..1399797 - 720 WP_044671062.1 O-methyltransferase -
NQZ84_RS06850 (NQZ84_06850) 1399872..1400420 - 549 WP_024385841.1 hypothetical protein -
NQZ84_RS06855 (NQZ84_06855) 1400431..1400874 - 444 WP_014637769.1 hypothetical protein -
NQZ84_RS06860 (NQZ84_06860) 1400876..1402678 - 1803 WP_074414178.1 oligoendopeptidase F -
NQZ84_RS06865 (NQZ84_06865) 1402788..1403087 - 300 WP_044670992.1 helix-turn-helix transcriptional regulator Antitoxin
NQZ84_RS06870 (NQZ84_06870) 1403077..1403442 - 366 WP_172107642.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ84_RS06875 (NQZ84_06875) 1403486..1404439 - 954 WP_257048379.1 competence protein CoiA family protein -
NQZ84_RS06880 (NQZ84_06880) 1404500..1406503 - 2004 WP_257048381.1 methionine--tRNA ligase -
NQZ84_RS06885 (NQZ84_06885) 1406616..1407008 - 393 WP_257048383.1 hypothetical protein -
NQZ84_RS06890 (NQZ84_06890) 1407091..1407231 + 141 WP_257048385.1 hypothetical protein -
NQZ84_RS06895 (NQZ84_06895) 1407207..1407656 - 450 WP_257048387.1 hypothetical protein -
NQZ84_RS06900 (NQZ84_06900) 1407710..1408330 - 621 WP_257048389.1 DUF3885 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14449.69 Da        Isoelectric Point: 10.1354

>T253183 WP_172107642.1 NZ_CP102094:c1403442-1403077 [Streptococcus suis]
MYTIYFYKDKNGREPVLEYLRELASKKGKDSRIKLNKINDYIELLSQLGTQIGEPYVKHLEGNIWELRPLRDRILFVAWY
EGSFVLLHHFVKRSQKTPRRELEKAQRELADLKERGINNGK

Download         Length: 366 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11044.70 Da        Isoelectric Point: 7.2059

>AT253183 WP_044670992.1 NZ_CP102094:c1403087-1402788 [Streptococcus suis]
MENSAIGSNWQSVRSELFSEKEIIESDLRVAIMSELIKARHEQGVSQKRLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLKQERHFQ

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BYX8

References