Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2793022..2793351 Replicon chromosome
Accession NZ_CP102070
Organism Enterococcus faecalis strain JF3A-4253

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag NP948_RS13710 Protein ID WP_002396786.1
Coordinates 2793208..2793351 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2793022..2793097 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP948_RS13690 (2788388) 2788388..2788603 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
NP948_RS13695 (2788742) 2788742..2789734 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
NP948_RS13700 (2789998) 2789998..2790636 - 639 WP_002375448.1 lytic polysaccharide monooxygenase -
NP948_RS13705 (2791322) 2791322..2792938 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
- (2793022) 2793022..2793097 - 76 NuclAT_7 - Antitoxin
- (2792995) 2792995..2793111 - 117 NuclAT_10 - -
NP948_RS13710 (2793208) 2793208..2793351 + 144 WP_002396786.1 putative holin-like toxin Toxin
- (2793495) 2793495..2793544 + 50 NuclAT_8 - -
- (2793283) 2793283..2793545 - 263 NuclAT_4 - -
NP948_RS13715 (2793546) 2793546..2798237 - 4692 WP_104806892.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T253132 WP_002396786.1 NZ_CP102070:2793208-2793351 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 76 bp

>AT253132 NZ_CP102070:c2793097-2793022 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References