Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2708338..2708780 Replicon chromosome
Accession NZ_CP102070
Organism Enterococcus faecalis strain JF3A-4253

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag NP948_RS13320 Protein ID WP_002392696.1
Coordinates 2708637..2708780 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2708338..2708471 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP948_RS13305 (2703885) 2703885..2704598 - 714 WP_016627522.1 trehalose operon repressor -
NP948_RS13310 (2704860) 2704860..2707604 + 2745 WP_016627523.1 glycosyl hydrolase family 65 protein -
NP948_RS13315 (2707619) 2707619..2708269 + 651 WP_002367457.1 beta-phosphoglucomutase -
- (2708338) 2708338..2708471 + 134 NuclAT_6 - Antitoxin
- (2708518) 2708518..2708663 + 146 NuclAT_5 - -
- (2708518) 2708518..2708704 + 187 NuclAT_9 - -
NP948_RS13320 (2708637) 2708637..2708780 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
NP948_RS13325 (2709188) 2709188..2709313 - 126 WP_002383214.1 hypothetical protein -
NP948_RS13330 (2709518) 2709518..2709724 + 207 WP_256969010.1 CPBP family intramembrane metalloprotease -
NP948_RS13335 (2709778) 2709778..2710749 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
NP948_RS13340 (2710924) 2710924..2711361 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
NP948_RS13345 (2711494) 2711494..2712048 - 555 WP_002378827.1 nucleoside triphosphate pyrophosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T253127 WP_002392696.1 NZ_CP102070:c2708780-2708637 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 134 bp

>AT253127 NZ_CP102070:2708338-2708471 [Enterococcus faecalis]
TGAAAAGAGAGAGATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCAATTGTATTATTTAAAAATA
ACCGTACTGGTCAAAGTAGACGGTTATTTTTATTGTCATTTTTAACAGCTTTTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References