Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2640592..2640852 Replicon chromosome
Accession NZ_CP102070
Organism Enterococcus faecalis strain JF3A-4253

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag NP948_RS13005 Protein ID WP_075551663.1
Coordinates 2640751..2640852 (-) Length 34 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2640592..2640802 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP948_RS12980 (2636276) 2636276..2637229 - 954 WP_002359060.1 siderophore ABC transporter substrate-binding protein -
NP948_RS12985 (2637268) 2637268..2638023 - 756 WP_002354962.1 ATP-binding cassette domain-containing protein -
NP948_RS12990 (2638020) 2638020..2638985 - 966 WP_002354961.1 iron chelate uptake ABC transporter family permease subunit -
NP948_RS12995 (2638982) 2638982..2639929 - 948 WP_002354960.1 iron chelate uptake ABC transporter family permease subunit -
NP948_RS13000 (2640114) 2640114..2640566 + 453 WP_010710887.1 YueI family protein -
- (2640592) 2640592..2640802 + 211 NuclAT_3 - Antitoxin
- (2640629) 2640629..2640806 + 178 NuclAT_11 - -
NP948_RS13005 (2640751) 2640751..2640852 - 102 WP_075551663.1 putative holin-like toxin Toxin
NP948_RS13010 (2641041) 2641041..2643311 - 2271 WP_002354955.1 bifunctional glutamate--cysteine ligase/glutathione synthetase -
NP948_RS13015 (2643482) 2643482..2643982 + 501 WP_016627679.1 cysteine hydrolase family protein -
NP948_RS13020 (2644434) 2644434..2645330 + 897 WP_002354953.1 YitT family protein -
NP948_RS13025 (2645381) 2645381..2645779 - 399 WP_002354951.1 glyoxalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-33)


Sequences

Toxin        


Download         Length: 34 a.a.        Molecular weight: 3599.34 Da        Isoelectric Point: 4.5869

>T253125 WP_075551663.1 NZ_CP102070:c2640852-2640751 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Download         Length: 102 bp

Antitoxin


Download         Length: 211 bp

>AT253125 NZ_CP102070:2640592-2640802 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCG
CCAGTTATAAGAACTGGTGGATTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References