Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 508305..508537 Replicon chromosome
Accession NZ_CP102070
Organism Enterococcus faecalis strain JF3A-4253

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag NP948_RS02600 Protein ID WP_002355568.1
Coordinates 508305..508421 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 508332..508537 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP948_RS02590 (503743) 503743..506001 + 2259 WP_002364805.1 DNA helicase PcrA -
NP948_RS02595 (506127) 506127..508157 + 2031 WP_104806903.1 NAD-dependent DNA ligase LigA -
NP948_RS02600 (508305) 508305..508421 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (508332) 508332..508537 - 206 NuclAT_2 - Antitoxin
NP948_RS02605 (508739) 508739..509044 + 306 WP_109537637.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
NP948_RS02610 (509044) 509044..510513 + 1470 WP_002398120.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
NP948_RS02615 (510513) 510513..511943 + 1431 WP_016627698.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
NP948_RS02620 (511962) 511962..513050 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T253121 WP_002355568.1 NZ_CP102070:508305-508421 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT253121 NZ_CP102070:c508537-508332 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCGTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References