Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2697945..2698282 Replicon chromosome
Accession NZ_CP102065
Organism Enterococcus faecalis strain JF3A-223

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag NP947_RS13155 Protein ID WP_002396786.1
Coordinates 2697945..2698088 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2698020..2698282 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP947_RS13135 2693223..2693438 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
NP947_RS13140 2693577..2694569 + 993 WP_002394775.1 biotin--[acetyl-CoA-carboxylase] ligase -
NP947_RS13145 2694736..2695374 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
NP947_RS13150 2696059..2697675 + 1617 WP_010710855.1 phosphatase PAP2/LCP family protein -
NP947_RS13155 2697945..2698088 + 144 WP_002396786.1 putative holin-like toxin Toxin
- 2698020..2698282 - 263 - - Antitoxin
NP947_RS13160 2698283..2702974 - 4692 WP_010710853.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T253114 WP_002396786.1 NZ_CP102065:2697945-2698088 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 263 bp

>AT253114 NZ_CP102065:c2698282-2698020 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References