Detailed information of TA system TA253110

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2554978..2555202
• Replicon: chromosome
• Accession: NZ_CP102065
• Organism: Enterococcus faecalis strain JF3A-223

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: NP947_RS12500
• Protein ID: WP_224561205.1
• Coordinates: 2555101..2555202 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2554978..2555156 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NP947_RS12475	2550625..2551578	-	954	WP_256969819.1	siderophore ABC transporter substrate-binding protein	-
NP947_RS12480	2551617..2552372	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
NP947_RS12485	2552369..2553334	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
NP947_RS12490	2553331..2554278	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
NP947_RS12495	2554463..2554915	+	453	WP_002378807.1	YueI family protein	-
-	2554978..2555156	+	179	-	-	Antitoxin
NP947_RS12500	2555101..2555202	-	102	WP_224561205.1	putative holin-like toxin	Toxin
NP947_RS12505	2555393..2557663	-	2271	WP_078122760.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
NP947_RS12510	2557834..2558340	+	507	WP_002378810.1	cysteine hydrolase family protein	-
NP947_RS12515	2558530..2559426	+	897	WP_002365354.1	YitT family protein	-
NP947_RS12520	2559477..2559875	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T253110 WP_224561205.1 NZ_CP102065:c2555202-2555101 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 179 bp

>AT253110 NZ_CP102065:2554978-2555156 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Structures

Antitoxin