Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3004109..3004711 Replicon chromosome
Accession NZ_CP102061
Organism Escherichia coli strain C31

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag NP943_RS14615 Protein ID WP_000897302.1
Coordinates 3004109..3004420 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NP943_RS14620 Protein ID WP_000356397.1
Coordinates 3004421..3004711 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP943_RS14590 (3000023) 3000023..3000622 + 600 WP_001296610.1 glucose-1-phosphatase -
NP943_RS14595 (3000616) 3000616..3001488 + 873 WP_000920762.1 virulence factor BrkB family protein -
NP943_RS14600 (3001485) 3001485..3001922 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
NP943_RS14605 (3001967) 3001967..3002908 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NP943_RS14610 (3002972) 3002972..3003880 - 909 WP_001385591.1 alpha/beta hydrolase -
NP943_RS14615 (3004109) 3004109..3004420 + 312 WP_000897302.1 hypothetical protein Toxin
NP943_RS14620 (3004421) 3004421..3004711 + 291 WP_000356397.1 NadS family protein Antitoxin
NP943_RS14625 (3005070) 3005070..3005348 + 279 WP_001296612.1 hypothetical protein -
NP943_RS14630 (3005745) 3005745..3005963 + 219 WP_001251293.1 CopG family transcriptional regulator -
NP943_RS14635 (3006148) 3006148..3006888 - 741 WP_000608806.1 hypothetical protein -
NP943_RS14640 (3006913) 3006913..3007761 - 849 WP_001038650.1 hypothetical protein -
NP943_RS14645 (3008051) 3008051..3008293 + 243 WP_001068514.1 CopG family transcriptional regulator -
NP943_RS14650 (3008475) 3008475..3009404 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T253086 WP_000897302.1 NZ_CP102061:3004109-3004420 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT253086 WP_000356397.1 NZ_CP102061:3004421-3004711 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References