Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2154575..2155374 Replicon chromosome
Accession NZ_CP102061
Organism Escherichia coli strain C31

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag NP943_RS10495 Protein ID WP_000347251.1
Coordinates 2154910..2155374 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NP943_RS10490 Protein ID WP_001296435.1
Coordinates 2154575..2154910 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP943_RS10475 (2150360) 2150360..2151130 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
NP943_RS10480 (2151146) 2151146..2152480 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
NP943_RS10485 (2152855) 2152855..2154426 + 1572 WP_001273763.1 galactarate dehydratase -
NP943_RS10490 (2154575) 2154575..2154910 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NP943_RS10495 (2154910) 2154910..2155374 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NP943_RS10500 (2155429) 2155429..2156238 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NP943_RS10505 (2156487) 2156487..2157767 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
NP943_RS10510 (2157790) 2157790..2158263 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NP943_RS10515 (2158274) 2158274..2159053 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NP943_RS10520 (2159043) 2159043..2159921 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NP943_RS10525 (2159939) 2159939..2160373 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T253084 WP_000347251.1 NZ_CP102061:2154910-2155374 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT253084 WP_001296435.1 NZ_CP102061:2154575-2154910 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References