Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1471512..1472025 Replicon chromosome
Accession NZ_CP101986
Organism Streptococcus mutans strain COCC33-14

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2J9QDB1
Locus tag NPS16_RS06770 Protein ID WP_002272281.1
Coordinates 1471771..1472025 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2J9QDE0
Locus tag NPS16_RS06765 Protein ID WP_002272282.1
Coordinates 1471512..1471778 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPS16_RS06760 (NPS16_06760) 1467909..1471145 - 3237 WP_258968841.1 ATP-dependent nuclease subunit B -
NPS16_RS06765 (NPS16_06765) 1471512..1471778 + 267 WP_002272282.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NPS16_RS06770 (NPS16_06770) 1471771..1472025 + 255 WP_002272281.1 Txe/YoeB family addiction module toxin Toxin
NPS16_RS06775 (NPS16_06775) 1472206..1474473 - 2268 WP_168749370.1 DEAD/DEAH box helicase family protein -
NPS16_RS06780 (NPS16_06780) 1474473..1476068 - 1596 WP_082999485.1 site-specific DNA-methyltransferase -
NPS16_RS06785 (NPS16_06785) 1476128..1476265 - 138 WP_226724684.1 hypothetical protein -
NPS16_RS06790 (NPS16_06790) 1476456..1476701 - 246 WP_258969291.1 SemiSWEET family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10466.84 Da        Isoelectric Point: 8.3862

>T253069 WP_002272281.1 NZ_CP101986:1471771-1472025 [Streptococcus mutans]
MFNFTEQAWQDYISWQQEDKKTLKRINRLIEDIKRNPFDGIGKPEPLKYRYSGAWSRRITDEHRLVYMIEESEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.88 Da        Isoelectric Point: 4.8723

>AT253069 WP_002272282.1 NZ_CP101986:1471512-1471778 [Streptococcus mutans]
MEAVVYSNFRNNLKDYMKKVNDEYEPLMVVNKNPDEDIVVLSKENWDSIQETIRLMNNEYLSDKVLSGIEQVKQRKITKH
ALLEVKDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QDB1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9QDE0

References