Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3483802..3484340 Replicon chromosome
Accession NZ_CP101940
Organism Salmonella enterica subsp. enterica strain QA-1986 974

Toxin (Protein)


Gene name yafQ Uniprot ID A0A7U1Q7V6
Locus tag NP448_RS17070 Protein ID WP_001521736.1
Coordinates 3484065..3484340 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A7U1KUN1
Locus tag NP448_RS17065 Protein ID WP_000729714.1
Coordinates 3483802..3484062 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP448_RS17050 (3479557) 3479557..3481110 + 1554 WP_058653096.1 TROVE domain-containing protein -
NP448_RS17055 (3481456) 3481456..3482670 + 1215 WP_001105525.1 RNA-splicing ligase RtcB -
NP448_RS17060 (3482674) 3482674..3483693 + 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
NP448_RS17065 (3483802) 3483802..3484062 + 261 WP_000729714.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NP448_RS17070 (3484065) 3484065..3484340 + 276 WP_001521736.1 type II toxin-antitoxin system YafQ family toxin Toxin
NP448_RS17075 (3484428) 3484428..3487133 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10618.25 Da        Isoelectric Point: 9.7714

>T253051 WP_001521736.1 NZ_CP101940:3484065-3484340 [Salmonella enterica subsp. enterica]
MGQRKIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIGPDWILIDKITDECLR
FERTGTHADLF

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9445.82 Da        Isoelectric Point: 4.6028

>AT253051 WP_000729714.1 NZ_CP101940:3483802-3484062 [Salmonella enterica subsp. enterica]
MAANALVRARIDETLKNQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U1Q7V6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U1KUN1

References