Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2873249..2873840 Replicon chromosome
Accession NC_015578
Organism Treponema primitia ZAS-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag TREPR_RS12500 Protein ID WP_041611190.1
Coordinates 2873249..2873527 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag TREPR_RS12505 Protein ID WP_015708685.1
Coordinates 2873541..2873840 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TREPR_RS12470 2868950..2870872 - 1923 WP_015708678.1 tetratricopeptide repeat protein -
TREPR_RS12480 2871593..2871979 - 387 WP_148257471.1 type II toxin-antitoxin system VapC family toxin -
TREPR_RS12485 2871988..2872233 - 246 WP_015708680.1 hypothetical protein -
TREPR_RS12490 2872435..2872662 - 228 WP_015708682.1 hypothetical protein -
TREPR_RS12495 2872672..2872947 - 276 WP_015708683.1 hypothetical protein -
TREPR_RS18660 2872987..2873133 + 147 WP_015708684.1 hypothetical protein -
TREPR_RS12500 2873249..2873527 + 279 WP_041611190.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TREPR_RS12505 2873541..2873840 + 300 WP_015708685.1 HigA family addiction module antidote protein Antitoxin
TREPR_RS18665 2873920..2874096 - 177 WP_015708686.1 hypothetical protein -
TREPR_RS12510 2874261..2876795 - 2535 WP_015708687.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-89)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10572.89 Da        Isoelectric Point: 6.9883

>T25305 WP_041611190.1 NC_015578:2873249-2873527 [Treponema primitia ZAS-2]
MIGSFKHKGLEQFFLTGTKRGIIPAHADKLERILDRLDASLSPSDMNLPGYRLHELSGQEKGVWSVSVNGNWRVTFRFEN
NDAHIVDYQDYH

Download         Length: 279 bp

>T25305 NC_015578:2873249-2873527 [Treponema primitia ZAS-2]
ATGATAGGTTCATTCAAGCACAAGGGACTTGAGCAATTCTTCTTGACGGGAACTAAGAGAGGGATCATTCCCGCTCACGC
AGATAAGCTGGAACGGATTCTTGATCGTTTAGATGCCAGTCTTTCACCCAGTGACATGAACTTACCCGGTTACCGTCTGC
ACGAACTTTCCGGGCAGGAGAAGGGCGTATGGTCGGTTTCGGTAAATGGGAATTGGCGTGTAACCTTTCGATTTGAAAAC
AATGACGCACACATTGTGGACTATCAGGATTATCATTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10905.76 Da        Isoelectric Point: 10.1478

>AT25305 WP_015708685.1 NC_015578:2873541-2873840 [Treponema primitia ZAS-2]
MKQTRKPVHPGKVFLEDVLVPLNLTITDAAALLGITRKTLSEFVNGKSALSPVMALRIAKATHTTAESWLTMQIKRTLWE
AEQYELSGIKDFPQVGVSA

Download         Length: 300 bp

>AT25305 NC_015578:2873541-2873840 [Treponema primitia ZAS-2]
ATGAAGCAAACACGAAAACCGGTGCATCCGGGGAAGGTTTTTTTGGAAGATGTTCTTGTTCCGCTTAATTTGACCATTAC
CGACGCGGCTGCATTACTCGGCATAACACGGAAAACGCTCTCTGAGTTTGTCAACGGGAAGTCGGCATTGAGTCCTGTAA
TGGCATTACGGATTGCCAAAGCTACCCACACCACAGCAGAAAGCTGGCTTACGATGCAAATAAAACGGACCCTTTGGGAA
GCAGAACAATATGAACTATCGGGTATTAAAGATTTTCCTCAAGTAGGCGTAAGCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References