Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2928296..2928898 Replicon chromosome
Accession NZ_CP101940
Organism Salmonella enterica subsp. enterica strain QA-1986 974

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NP448_RS14460 Protein ID WP_001159630.1
Coordinates 2928587..2928898 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NP448_RS14455 Protein ID WP_000362050.1
Coordinates 2928296..2928586 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP448_RS14440 (2925789) 2925789..2926691 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
NP448_RS14445 (2926688) 2926688..2927323 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NP448_RS14450 (2927320) 2927320..2928249 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NP448_RS14455 (2928296) 2928296..2928586 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NP448_RS14460 (2928587) 2928587..2928898 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NP448_RS14465 (2929116) 2929116..2930045 + 930 WP_001127704.1 alpha/beta hydrolase -
NP448_RS14470 (2930131) 2930131..2930442 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NP448_RS14475 (2930439) 2930439..2930885 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NP448_RS14480 (2930900) 2930900..2931841 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NP448_RS14485 (2931886) 2931886..2932323 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
NP448_RS14490 (2932320) 2932320..2933192 - 873 WP_000921423.1 virulence factor BrkB family protein -
NP448_RS14495 (2933186) 2933186..2933785 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T253048 WP_001159630.1 NZ_CP101940:c2928898-2928587 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT253048 WP_000362050.1 NZ_CP101940:c2928586-2928296 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References