Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4269357..4269615 Replicon chromosome
Accession NZ_CP101925
Organism Escherichia coli strain Seattle 1946

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NP429_RS20600 Protein ID WP_000809168.1
Coordinates 4269463..4269615 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4269357..4269414 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP429_RS20585 4265186..4266445 - 1260 WP_000494928.1 hypothetical protein -
NP429_RS20590 4266574..4268067 - 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
NP429_RS20595 4268087..4268848 - 762 WP_001274832.1 outer membrane protein OmpK -
- 4269357..4269414 - 58 - - Antitoxin
NP429_RS20600 4269463..4269615 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
NP429_RS20605 4269720..4270850 - 1131 WP_001118465.1 molecular chaperone DnaJ -
NP429_RS20610 4270939..4272855 - 1917 WP_000516135.1 molecular chaperone DnaK -
NP429_RS20615 4273227..4273631 + 405 WP_000843687.1 DUF2541 family protein -
NP429_RS20620 4273657..4274370 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T253003 WP_000809168.1 NZ_CP101925:4269463-4269615 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT253003 NZ_CP101925:c4269414-4269357 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References