253001

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4033068..4033866 Replicon chromosome
Accession NZ_CP101925
Organism Escherichia coli strain Seattle 1946

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag NP429_RS19485 Protein ID WP_000854730.1
Coordinates 4033489..4033866 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag NP429_RS19480 Protein ID WP_001285481.1
Coordinates 4033068..4033442 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP429_RS19440 (4029043) 4029043..4029495 + 453 WP_000682723.1 hypothetical protein -
NP429_RS19445 (4029613) 4029613..4029846 + 234 WP_001213776.1 DUF905 family protein -
NP429_RS19450 (4029946) 4029946..4030767 + 822 WP_001234359.1 DUF932 domain-containing protein -
NP429_RS19455 (4030767) 4030767..4031012 + 246 WP_001164966.1 hypothetical protein -
NP429_RS19460 (4031106) 4031106..4031579 + 474 WP_001313575.1 antirestriction protein -
NP429_RS19465 (4031595) 4031595..4032071 + 477 WP_001313574.1 RadC family protein -
NP429_RS19470 (4032134) 4032134..4032355 + 222 WP_000692315.1 DUF987 domain-containing protein -
NP429_RS19475 (4032374) 4032374..4033018 + 645 WP_000086761.1 hypothetical protein -
NP429_RS19480 (4033068) 4033068..4033442 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NP429_RS19485 (4033489) 4033489..4033866 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
NP429_RS19490 (4033863) 4033863..4034355 + 493 Protein_3824 DUF5983 family protein -
NP429_RS19495 (4034434) 4034434..4035422 - 989 Protein_3825 IS630 family transposase -
NP429_RS19500 (4035570) 4035570..4035758 - 189 Protein_3826 IS66 family transposase -
NP429_RS19505 (4035819) 4035819..4036952 + 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
NP429_RS19510 (4037206) 4037206..4038610 - 1405 Protein_3828 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4033068..4043555 10487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T253001 WP_000854730.1 NZ_CP101925:4033489-4033866 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT253001 WP_001285481.1 NZ_CP101925:4033068-4033442 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References