Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1919389..1919891 Replicon chromosome
Accession NZ_CP101925
Organism Escherichia coli strain Seattle 1946

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag NP429_RS09065 Protein ID WP_000767822.1
Coordinates 1919637..1919891 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NP429_RS09060 Protein ID WP_001259255.1
Coordinates 1919389..1919640 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP429_RS09035 (1914567) 1914567..1915634 - 1068 WP_000080122.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NP429_RS09040 (1915634) 1915634..1916704 - 1071 WP_000108995.1 histidinol-phosphate transaminase -
NP429_RS09045 (1916701) 1916701..1918005 - 1305 WP_001297912.1 histidinol dehydrogenase -
NP429_RS09050 (1918011) 1918011..1918910 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NP429_RS09055 (1919056) 1919056..1919106 - 51 WP_001364200.1 his operon leader peptide -
NP429_RS09060 (1919389) 1919389..1919640 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NP429_RS09065 (1919637) 1919637..1919891 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NP429_RS09070 (1919974) 1919974..1920798 + 825 WP_000754733.1 SDR family oxidoreductase -
NP429_RS09075 (1920844) 1920844..1921773 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
NP429_RS09080 (1921988) 1921988..1922050 + 63 WP_010723108.1 membrane protein YoeI -
NP429_RS09085 (1922040) 1922040..1923398 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T252990 WP_000767822.1 NZ_CP101925:1919637-1919891 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT252990 WP_001259255.1 NZ_CP101925:1919389-1919640 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References