Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1777764..1778266 Replicon chromosome
Accession NZ_CP101922
Organism Escherichia coli strain JCC-EE 7

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NP442_RS08465 Protein ID WP_098717182.1
Coordinates 1778012..1778266 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NP442_RS08460 Protein ID WP_001259255.1
Coordinates 1777764..1778015 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP442_RS08435 (1772942) 1772942..1774009 - 1068 WP_000080145.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NP442_RS08440 (1774009) 1774009..1775079 - 1071 WP_000108954.1 histidinol-phosphate transaminase -
NP442_RS08445 (1775082) 1775082..1776380 - 1299 WP_001735396.1 histidinol dehydrogenase -
NP442_RS08450 (1776386) 1776386..1777285 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NP442_RS08455 (1777431) 1777431..1777481 - 51 WP_001364200.1 his operon leader peptide -
NP442_RS08460 (1777764) 1777764..1778015 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NP442_RS08465 (1778012) 1778012..1778266 + 255 WP_098717182.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NP442_RS08470 (1778349) 1778349..1779173 + 825 WP_000754737.1 SDR family oxidoreductase -
NP442_RS08475 (1779219) 1779219..1780148 + 930 WP_098717181.1 LysR substrate-binding domain-containing protein -
NP442_RS08480 (1780363) 1780363..1780425 + 63 WP_010723108.1 membrane protein YoeI -
NP442_RS08485 (1780415) 1780415..1781773 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NP442_RS08490 (1781952) 1781952..1783010 + 1059 WP_000492340.1 thiosulfate utilization transporter TsuA/YeeE -
NP442_RS08495 (1783024) 1783024..1783251 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10213.67 Da        Isoelectric Point: 8.0353

>T252972 WP_098717182.1 NZ_CP101922:1778012-1778266 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRMPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT252972 WP_001259255.1 NZ_CP101922:1777764-1778015 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References