Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 697886..698579 Replicon chromosome
Accession NZ_CP101922
Organism Escherichia coli strain JCC-EE 7

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NP442_RS03440 Protein ID WP_000415584.1
Coordinates 697886..698182 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NP442_RS03445 Protein ID WP_000650107.1
Coordinates 698184..698579 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP442_RS03405 (692974) 692974..693288 - 315 WP_000958598.1 putative quinol monooxygenase -
NP442_RS03410 (693319) 693319..693900 - 582 WP_098717236.1 NADPH:quinone oxidoreductase MdaB -
NP442_RS03415 (694219) 694219..694551 + 333 WP_000917684.1 DUF2645 family protein -
NP442_RS03420 (694597) 694597..695946 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
NP442_RS03425 (695943) 695943..696602 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NP442_RS03430 (696754) 696754..697146 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NP442_RS03435 (697199) 697199..697681 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NP442_RS03440 (697886) 697886..698182 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NP442_RS03445 (698184) 698184..698579 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NP442_RS03450 (698712) 698712..700319 + 1608 WP_001735743.1 ABC transporter substrate-binding protein -
NP442_RS03455 (700457) 700457..702715 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T252968 WP_000415584.1 NZ_CP101922:697886-698182 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT252968 WP_000650107.1 NZ_CP101922:698184-698579 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References