Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 589717..590516 Replicon chromosome
Accession NZ_CP101922
Organism Escherichia coli strain JCC-EE 7

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag NP442_RS02910 Protein ID WP_000347273.1
Coordinates 589717..590181 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NP442_RS02915 Protein ID WP_001307405.1
Coordinates 590181..590516 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP442_RS02880 (584718) 584718..585152 - 435 WP_000948842.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NP442_RS02885 (585170) 585170..586048 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NP442_RS02890 (586038) 586038..586817 - 780 WP_000406208.1 PTS N-acetylgalactosamine transporter subunit IIC -
NP442_RS02895 (586828) 586828..587301 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
NP442_RS02900 (587324) 587324..588604 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NP442_RS02905 (588853) 588853..589662 + 810 WP_098717167.1 aga operon transcriptional regulator AgaR -
NP442_RS02910 (589717) 589717..590181 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NP442_RS02915 (590181) 590181..590516 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NP442_RS02920 (590665) 590665..592236 - 1572 WP_001273753.1 galactarate dehydratase -
NP442_RS02925 (592611) 592611..593945 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NP442_RS02930 (593961) 593961..594731 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T252966 WP_000347273.1 NZ_CP101922:c590181-589717 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT252966 WP_001307405.1 NZ_CP101922:c590516-590181 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References