252965

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4588035..4588637 Replicon chromosome
Accession NZ_CP101921
Organism Escherichia coli strain QA-1986 83

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NP438_RS22055 Protein ID WP_000897305.1
Coordinates 4588326..4588637 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NP438_RS22050 Protein ID WP_000356397.1
Coordinates 4588035..4588325 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP438_RS22025 (4583961) 4583961..4584863 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NP438_RS22030 (4584860) 4584860..4585495 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NP438_RS22035 (4585492) 4585492..4586421 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NP438_RS22040 (4586751) 4586751..4586993 - 243 WP_001086388.1 protein YiiF -
NP438_RS22045 (4587212) 4587212..4587430 - 219 WP_001297075.1 CopG family transcriptional regulator -
NP438_RS22050 (4588035) 4588035..4588325 - 291 WP_000356397.1 NadS family protein Antitoxin
NP438_RS22055 (4588326) 4588326..4588637 - 312 WP_000897305.1 hypothetical protein Toxin
NP438_RS22060 (4588866) 4588866..4589774 + 909 WP_001162704.1 alpha/beta hydrolase -
NP438_RS22065 (4589838) 4589838..4590779 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NP438_RS22070 (4590824) 4590824..4591261 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NP438_RS22075 (4591258) 4591258..4592130 - 873 WP_000920762.1 virulence factor BrkB family protein -
NP438_RS22080 (4592124) 4592124..4592723 - 600 WP_001295269.1 glucose-1-phosphatase -
NP438_RS22085 (4592822) 4592822..4593607 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T252965 WP_000897305.1 NZ_CP101921:c4588637-4588326 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT252965 WP_000356397.1 NZ_CP101921:c4588325-4588035 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References