252961

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3750810..3751351 Replicon chromosome
Accession NZ_CP101921
Organism Escherichia coli strain QA-1986 83

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag NP438_RS18225 Protein ID WP_000615976.1
Coordinates 3751073..3751351 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NP438_RS18220 Protein ID WP_000729704.1
Coordinates 3750810..3751070 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP438_RS18195 (3746593) 3746593..3747378 - 786 WP_000207589.1 putative lateral flagellar export/assembly protein LafU -
NP438_RS18200 (3747350) 3747350..3749062 + 1713 Protein_3564 flagellar biosynthesis protein FlhA -
NP438_RS18205 (3749167) 3749167..3749445 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NP438_RS18210 (3749438) 3749438..3749794 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
NP438_RS18215 (3749851) 3749851..3750624 - 774 WP_001396221.1 C40 family peptidase -
NP438_RS18220 (3750810) 3750810..3751070 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NP438_RS18225 (3751073) 3751073..3751351 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NP438_RS18230 (3751507) 3751507..3752247 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NP438_RS18235 (3752218) 3752218..3752985 - 768 WP_000333380.1 class II glutamine amidotransferase -
NP438_RS18240 (3753090) 3753090..3753668 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T252961 WP_000615976.1 NZ_CP101921:3751073-3751351 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT252961 WP_000729704.1 NZ_CP101921:3750810-3751070 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References