252949

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1861347..1861849 Replicon chromosome
Accession NZ_CP101921
Organism Escherichia coli strain QA-1986 83

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NP438_RS08935 Protein ID WP_000767829.1
Coordinates 1861595..1861849 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NP438_RS08930 Protein ID WP_001259255.1
Coordinates 1861347..1861598 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP438_RS08905 (1856525) 1856525..1857592 - 1068 WP_000080109.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NP438_RS08910 (1857592) 1857592..1858662 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
NP438_RS08915 (1858659) 1858659..1859963 - 1305 WP_001345878.1 histidinol dehydrogenase -
NP438_RS08920 (1859969) 1859969..1860868 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NP438_RS08925 (1861014) 1861014..1861064 - 51 WP_001364200.1 his operon leader peptide -
NP438_RS08930 (1861347) 1861347..1861598 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NP438_RS08935 (1861595) 1861595..1861849 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NP438_RS08940 (1861932) 1861932..1862756 + 825 WP_000754737.1 SDR family oxidoreductase -
NP438_RS08945 (1862802) 1862802..1863731 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NP438_RS08950 (1863946) 1863946..1864008 + 63 WP_010723108.1 membrane protein YoeI -
NP438_RS08955 (1863998) 1863998..1865356 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NP438_RS08960 (1865535) 1865535..1866593 + 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
NP438_RS08965 (1866607) 1866607..1866834 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T252949 WP_000767829.1 NZ_CP101921:1861595-1861849 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT252949 WP_001259255.1 NZ_CP101921:1861347-1861598 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References