Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 593693..594492 Replicon chromosome
Accession NZ_CP101921
Organism Escherichia coli strain QA-1986 83

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag NP438_RS02895 Protein ID WP_000347253.1
Coordinates 593693..594157 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag NP438_RS02900 Protein ID WP_024251361.1
Coordinates 594157..594492 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP438_RS02865 (588694) 588694..589128 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NP438_RS02870 (589146) 589146..590024 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NP438_RS02875 (590014) 590014..590793 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NP438_RS02880 (590804) 590804..591277 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NP438_RS02885 (591300) 591300..592580 - 1281 WP_000681910.1 tagatose-bisphosphate aldolase subunit KbaZ -
NP438_RS02890 (592829) 592829..593638 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NP438_RS02895 (593693) 593693..594157 - 465 WP_000347253.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NP438_RS02900 (594157) 594157..594492 - 336 WP_024251361.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NP438_RS02905 (594641) 594641..596212 - 1572 WP_001273766.1 galactarate dehydratase -
NP438_RS02910 (596587) 596587..597921 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NP438_RS02915 (597937) 597937..598707 + 771 WP_001058226.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17764.14 Da        Isoelectric Point: 9.4947

>T252945 WP_000347253.1 NZ_CP101921:c594157-593693 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12348.90 Da        Isoelectric Point: 4.8616

>AT252945 WP_024251361.1 NZ_CP101921:c594492-594157 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
SQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References