Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4870871..4871473 Replicon chromosome
Accession NZ_CP101920
Organism Escherichia coli strain QA-1986 630

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NP447_RS23755 Protein ID WP_000897305.1
Coordinates 4871162..4871473 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NP447_RS23750 Protein ID WP_000356397.1
Coordinates 4870871..4871161 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP447_RS23725 (4866796) 4866796..4867698 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NP447_RS23730 (4867695) 4867695..4868330 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NP447_RS23735 (4868327) 4868327..4869256 + 930 WP_000027707.1 formate dehydrogenase accessory protein FdhE -
NP447_RS23740 (4869586) 4869586..4869828 - 243 WP_001087409.1 protein YiiF -
NP447_RS23745 (4870048) 4870048..4870266 - 219 WP_001315930.1 CopG family transcriptional regulator -
NP447_RS23750 (4870871) 4870871..4871161 - 291 WP_000356397.1 NadS family protein Antitoxin
NP447_RS23755 (4871162) 4871162..4871473 - 312 WP_000897305.1 hypothetical protein Toxin
NP447_RS23760 (4871702) 4871702..4872610 + 909 WP_001162704.1 alpha/beta hydrolase -
NP447_RS23765 (4872674) 4872674..4873615 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NP447_RS23770 (4873660) 4873660..4874097 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NP447_RS23775 (4874094) 4874094..4874966 - 873 WP_000920762.1 virulence factor BrkB family protein -
NP447_RS23780 (4874960) 4874960..4875559 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T252943 WP_000897305.1 NZ_CP101920:c4871473-4871162 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT252943 WP_000356397.1 NZ_CP101920:c4871161-4870871 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References