Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
Location | 714141..714834 | Replicon | chromosome |
Accession | NZ_CP101915 | ||
Organism | Escherichia coli strain Evo1 |
Toxin (Protein)
Gene name | mqsR | Uniprot ID | U9ZN09 |
Locus tag | NP443_RS03505 | Protein ID | WP_000415585.1 |
Coordinates | 714141..714437 (+) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | mqsA | Uniprot ID | S1EBV2 |
Locus tag | NP443_RS03510 | Protein ID | WP_000650107.1 |
Coordinates | 714439..714834 (+) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NP443_RS03470 (709275) | 709275..709754 | + | 480 | WP_000065332.1 | Hcp family type VI secretion system effector | - |
NP443_RS03475 (709757) | 709757..710467 | + | 711 | WP_000834030.1 | hypothetical protein | - |
NP443_RS03480 (710474) | 710474..710806 | + | 333 | WP_000914690.1 | DUF2645 family protein | - |
NP443_RS03485 (710852) | 710852..712201 | - | 1350 | WP_000673358.1 | quorum sensing histidine kinase QseC | - |
NP443_RS03490 (712198) | 712198..712857 | - | 660 | WP_001221502.1 | quorum sensing response regulator transcription factor QseB | - |
NP443_RS03495 (713009) | 713009..713401 | + | 393 | WP_000712658.1 | OB fold stress tolerance protein YgiW | - |
NP443_RS03500 (713454) | 713454..713936 | + | 483 | WP_000183505.1 | GyrI-like domain-containing protein | - |
NP443_RS03505 (714141) | 714141..714437 | + | 297 | WP_000415585.1 | type II toxin-antitoxin system toxin MqsR | Toxin |
NP443_RS03510 (714439) | 714439..714834 | + | 396 | WP_000650107.1 | type II toxin-antitoxin system antitoxin MqsA | Antitoxin |
NP443_RS03515 (714967) | 714967..716574 | + | 1608 | WP_001375094.1 | ABC transporter substrate-binding protein | - |
NP443_RS03520 (716712) | 716712..718970 | + | 2259 | WP_001281841.1 | DNA topoisomerase IV subunit A | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11261.99 Da Isoelectric Point: 8.9070
>T252906 WP_000415585.1 NZ_CP101915:714141-714437 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
Download Length: 297 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14703.10 Da Isoelectric Point: 9.2136
>AT252906 WP_000650107.1 NZ_CP101915:714439-714834 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | U9ZN09 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LU65 |