Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 599058..599857 Replicon chromosome
Accession NZ_CP101915
Organism Escherichia coli strain Evo1

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag NP443_RS02940 Protein ID WP_000347273.1
Coordinates 599058..599522 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NP443_RS02945 Protein ID WP_001307405.1
Coordinates 599522..599857 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP443_RS02910 (594059) 594059..594493 - 435 WP_032182759.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NP443_RS02915 (594511) 594511..595389 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
NP443_RS02920 (595379) 595379..596158 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NP443_RS02925 (596169) 596169..596642 - 474 WP_024229000.1 PTS N-acetylgalactosamine transporter subunit IIB -
NP443_RS02930 (596665) 596665..597945 - 1281 WP_074514777.1 tagatose-bisphosphate aldolase subunit KbaZ -
NP443_RS02935 (598194) 598194..599003 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NP443_RS02940 (599058) 599058..599522 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NP443_RS02945 (599522) 599522..599857 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NP443_RS02950 (600006) 600006..601577 - 1572 WP_074514537.1 galactarate dehydratase -
NP443_RS02955 (601952) 601952..603286 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NP443_RS02960 (603302) 603302..604072 + 771 WP_073461569.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T252905 WP_000347273.1 NZ_CP101915:c599522-599058 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT252905 WP_001307405.1 NZ_CP101915:c599857-599522 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References