Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5801751..5802346 Replicon chromosome
Accession NZ_CP101912
Organism Pseudomonas aeruginosa strain ATCC 27853

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag NP446_RS27485 Protein ID WP_003117425.1
Coordinates 5802068..5802346 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NP446_RS27480 Protein ID WP_003099268.1
Coordinates 5801751..5802056 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP446_RS27450 (NP446_27450) 5797204..5797494 - 291 WP_023083237.1 DUF5447 family protein -
NP446_RS27455 (NP446_27455) 5797706..5797978 - 273 WP_003115921.1 hypothetical protein -
NP446_RS27460 (NP446_27460) 5798088..5798354 + 267 WP_016852153.1 hypothetical protein -
NP446_RS27465 (NP446_27465) 5798486..5799322 + 837 WP_223656480.1 helix-turn-helix domain-containing protein -
NP446_RS27470 (NP446_27470) 5799297..5800835 + 1539 WP_023082696.1 GNAT family N-acetyltransferase -
NP446_RS27475 (NP446_27475) 5800847..5801374 - 528 WP_071535723.1 ATP-binding protein -
NP446_RS27480 (NP446_27480) 5801751..5802056 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
NP446_RS27485 (NP446_27485) 5802068..5802346 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP446_RS27490 (NP446_27490) 5802399..5802527 - 129 Protein_5434 integrase -
NP446_RS27495 (NP446_27495) 5802675..5804903 + 2229 WP_003099265.1 TonB-dependent receptor -
NP446_RS27500 (NP446_27500) 5804973..5805620 - 648 WP_003095021.1 carbonate dehydratase -
NP446_RS27505 (NP446_27505) 5805682..5806920 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T252901 WP_003117425.1 NZ_CP101912:c5802346-5802068 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT252901 WP_003099268.1 NZ_CP101912:c5802056-5801751 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References