Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5292087..5292682 Replicon chromosome
Accession NZ_CP101911
Organism Pseudomonas aeruginosa strain NWRC-1223

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag NP444_RS24550 Protein ID WP_003113526.1
Coordinates 5292404..5292682 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NP444_RS24545 Protein ID WP_003113527.1
Coordinates 5292087..5292392 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP444_RS24520 (NP444_24520) 5287247..5287582 + 336 WP_256713333.1 hypothetical protein -
NP444_RS24525 (NP444_24525) 5287592..5287981 + 390 WP_256713334.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -
NP444_RS24530 (NP444_24530) 5288574..5288798 + 225 Protein_4844 HNH endonuclease -
NP444_RS24535 (NP444_24535) 5289173..5290933 - 1761 WP_162598213.1 HEPN domain-containing protein -
NP444_RS24540 (NP444_24540) 5291337..5291750 - 414 WP_109392601.1 hypothetical protein -
NP444_RS24545 (NP444_24545) 5292087..5292392 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
NP444_RS24550 (NP444_24550) 5292404..5292682 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP444_RS24555 (NP444_24555) 5292735..5292863 - 129 Protein_4849 integrase -
NP444_RS24560 (NP444_24560) 5293011..5295239 + 2229 WP_003099265.1 TonB-dependent receptor -
NP444_RS24565 (NP444_24565) 5295309..5295953 - 645 WP_016253921.1 carbonate dehydratase -
NP444_RS24570 (NP444_24570) 5296015..5297253 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T252893 WP_003113526.1 NZ_CP101911:c5292682-5292404 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT252893 WP_003113527.1 NZ_CP101911:c5292392-5292087 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References