Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1329556..1330142 Replicon chromosome
Accession NZ_CP101910
Organism Pseudomonas putida strain ATCC 12633

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag NP430_RS05910 Protein ID WP_080642811.1
Coordinates 1329864..1330142 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag NP430_RS05905 Protein ID WP_003252274.1
Coordinates 1329556..1329855 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP430_RS05880 (NP430_05880) 1325409..1326218 + 810 WP_162471774.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -
NP430_RS05885 (NP430_05885) 1326328..1326738 - 411 WP_016501173.1 SufE family protein -
NP430_RS05890 (NP430_05890) 1326735..1327940 - 1206 WP_016501172.1 cysteine desulfurase -
NP430_RS05895 (NP430_05895) 1328018..1329052 - 1035 WP_016485200.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
NP430_RS05900 (NP430_05900) 1329084..1329431 - 348 WP_003252272.1 ArsC family reductase -
NP430_RS05905 (NP430_05905) 1329556..1329855 - 300 WP_003252274.1 type II toxin-antitoxin system antitoxin GraA Antitoxin
NP430_RS05910 (NP430_05910) 1329864..1330142 - 279 WP_080642811.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP430_RS05915 (NP430_05915) 1330395..1332041 + 1647 WP_016501171.1 Na+/H+ antiporter -
NP430_RS05920 (NP430_05920) 1332183..1333379 - 1197 WP_016501170.1 succinyldiaminopimelate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-90)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10345.65 Da        Isoelectric Point: 7.2152

>T252881 WP_080642811.1 NZ_CP101910:c1330142-1329864 [Pseudomonas putida]
IIQSFSCADTEALFTTGKTRRCSDIKSVAERKLAMLDAATALRDLRSPPGNRLESLSGDRAGQHSIRVNDQWRLCFTWTE
HGPINVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10891.52 Da        Isoelectric Point: 5.6714

>AT252881 WP_003252274.1 NZ_CP101910:c1329855-1329556 [Pseudomonas putida]
MLKNGMRPIHPGEILREDFQKEMGFSAAALARALGVATPTVNNILRERGGVSADMALRLSICLDTTPEFWLNLQTAFDLR
TAEQQHGDEIIGSVQRLVA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References