252871

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2894149..2894751 Replicon chromosome
Accession NZ_CP101907
Organism Salmonella enterica subsp. enterica strain QA-1986 973

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NP441_RS14245 Protein ID WP_001159630.1
Coordinates 2894440..2894751 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NP441_RS14240 Protein ID WP_000362050.1
Coordinates 2894149..2894439 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP441_RS14225 (2891642) 2891642..2892544 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
NP441_RS14230 (2892541) 2892541..2893176 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NP441_RS14235 (2893173) 2893173..2894102 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NP441_RS14240 (2894149) 2894149..2894439 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NP441_RS14245 (2894440) 2894440..2894751 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NP441_RS14250 (2894969) 2894969..2895898 + 930 WP_001127704.1 alpha/beta hydrolase -
NP441_RS14255 (2895984) 2895984..2896295 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NP441_RS14260 (2896292) 2896292..2896738 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NP441_RS14265 (2896753) 2896753..2897694 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NP441_RS14270 (2897739) 2897739..2898176 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
NP441_RS14275 (2898173) 2898173..2899045 - 873 WP_000921423.1 virulence factor BrkB family protein -
NP441_RS14280 (2899039) 2899039..2899638 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T252871 WP_001159630.1 NZ_CP101907:c2894751-2894440 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT252871 WP_000362050.1 NZ_CP101907:c2894439-2894149 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References