Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 633290..633812 Replicon chromosome
Accession NZ_CP101907
Organism Salmonella enterica subsp. enterica strain QA-1986 973

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag NP441_RS03260 Protein ID WP_000221345.1
Coordinates 633528..633812 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NP441_RS03255 Protein ID WP_000885424.1
Coordinates 633290..633538 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP441_RS03230 (628506) 628506..629972 + 1467 WP_000987828.1 hypothetical protein -
NP441_RS03235 (630780) 630780..631494 + 715 Protein_631 helix-turn-helix domain-containing protein -
NP441_RS03240 (631550) 631550..632458 - 909 WP_010989018.1 hypothetical protein -
NP441_RS03245 (632601) 632601..632933 - 333 WP_000253154.1 DUF1493 family protein -
NP441_RS03250 (632923) 632923..633138 - 216 WP_000206207.1 hypothetical protein -
NP441_RS03255 (633290) 633290..633538 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NP441_RS03260 (633528) 633528..633812 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP441_RS03265 (633983) 633983..634372 + 390 WP_000194089.1 RidA family protein -
NP441_RS03270 (634424) 634424..635503 - 1080 WP_058653180.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NP441_RS03275 (635685) 635685..636173 - 489 WP_001293637.1 MarR family winged helix-turn-helix transcriptional regulator -
NP441_RS03280 (636218) 636218..637726 + 1509 WP_058653181.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 630242..640583 10341


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T252865 WP_000221345.1 NZ_CP101907:633528-633812 [Salmonella enterica subsp. enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT252865 WP_000885424.1 NZ_CP101907:633290-633538 [Salmonella enterica subsp. enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References