Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1322296..1322891 Replicon chromosome
Accession NZ_CP101885
Organism Pseudomonas aeruginosa strain M27432

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag NOQ96_RS06270 Protein ID WP_003113526.1
Coordinates 1322296..1322574 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NOQ96_RS06275 Protein ID WP_003133769.1
Coordinates 1322586..1322891 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ96_RS06250 (NOQ96_06250) 1317721..1318959 + 1239 WP_003095023.1 C69 family dipeptidase -
NOQ96_RS06255 (NOQ96_06255) 1319021..1319668 + 648 WP_003095021.1 carbonate dehydratase -
NOQ96_RS06260 (NOQ96_06260) 1319739..1321967 - 2229 WP_023104079.1 TonB-dependent receptor -
NOQ96_RS06265 (NOQ96_06265) 1322115..1322243 + 129 Protein_1231 integrase -
NOQ96_RS06270 (NOQ96_06270) 1322296..1322574 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOQ96_RS06275 (NOQ96_06275) 1322586..1322891 + 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
NOQ96_RS06285 (NOQ96_06285) 1323563..1324705 + 1143 WP_023098851.1 STY4528 family pathogenicity island replication protein -
NOQ96_RS06290 (NOQ96_06290) 1325306..1326169 + 864 WP_023098850.1 integrase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T252855 WP_003113526.1 NZ_CP101885:1322296-1322574 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT252855 WP_003133769.1 NZ_CP101885:1322586-1322891 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References