Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 26305..26719 | Replicon | plasmid p3 |
| Accession | NZ_CP101880 | ||
| Organism | Klebsiella pneumoniae strain KPA1 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | G9G195 |
| Locus tag | NNX43_RS27105 | Protein ID | WP_001323520.1 |
| Coordinates | 26603..26719 (+) | Length | 39 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 26305..26517 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NNX43_RS27060 (21619) | 21619..22593 | + | 975 | WP_004187382.1 | plasmid segregation protein ParM | - |
| NNX43_RS27065 (22596) | 22596..23039 | + | 444 | WP_004187380.1 | plasmid partitioning/stability family protein | - |
| NNX43_RS27070 (23049) | 23049..23612 | + | 564 | WP_019725065.1 | phospholipase D family protein | - |
| NNX43_RS27075 (23730) | 23730..24236 | + | 507 | WP_004187377.1 | hypothetical protein | - |
| NNX43_RS27080 (24229) | 24229..24708 | + | 480 | WP_004187375.1 | hypothetical protein | - |
| NNX43_RS27085 (24737) | 24737..25147 | + | 411 | WP_004206907.1 | hypothetical protein | - |
| NNX43_RS27090 (25265) | 25265..25528 | + | 264 | WP_004187372.1 | hypothetical protein | - |
| - (26305) | 26305..26517 | + | 213 | NuclAT_0 | - | Antitoxin |
| - (26305) | 26305..26517 | + | 213 | NuclAT_0 | - | Antitoxin |
| - (26305) | 26305..26517 | + | 213 | NuclAT_0 | - | Antitoxin |
| - (26305) | 26305..26517 | + | 213 | NuclAT_0 | - | Antitoxin |
| NNX43_RS27100 (26503) | 26503..26652 | + | 150 | Protein_39 | plasmid maintenance protein Mok | - |
| NNX43_RS27105 (26603) | 26603..26719 | + | 117 | WP_001323520.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| NNX43_RS27110 (27020) | 27020..27316 | - | 297 | Protein_41 | hypothetical protein | - |
| NNX43_RS27115 (27616) | 27616..27912 | + | 297 | WP_001272251.1 | hypothetical protein | - |
| NNX43_RS27120 (28023) | 28023..28844 | + | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
| NNX43_RS27125 (29141) | 29141..29731 | - | 591 | WP_000252683.1 | transglycosylase SLT domain-containing protein | - |
| NNX43_RS27130 (30064) | 30064..30447 | + | 384 | WP_001151529.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| NNX43_RS27135 (30639) | 30639..31286 | + | 648 | WP_000332523.1 | transcriptional regulator TraJ family protein | - |
| NNX43_RS27140 (31406) | 31406..31633 | + | 228 | WP_000589556.1 | conjugal transfer relaxosome protein TraY | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaOXA-48 | - | 1..68908 | 68908 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 39 a.a. Molecular weight: 4455.23 Da Isoelectric Point: 8.5110
>T252849 WP_001323520.1 NZ_CP101880:26603-26719 [Klebsiella pneumoniae]
VCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 117 bp
Antitoxin
Download Length: 213 bp
>AT252849 NZ_CP101880:26305-26517 [Klebsiella pneumoniae]
CCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATGGGCTATGATGTG
CCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGAAGATAGCCCCGT
AGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
CCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATGGGCTATGATGTG
CCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGAAGATAGCCCCGT
AGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
