Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 354812..355452 Replicon chromosome
Accession NZ_CP101877
Organism Klebsiella pneumoniae strain KPA1

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag NNX43_RS01645 Protein ID WP_016529833.1
Coordinates 354812..355159 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NNX43_RS01650 Protein ID WP_040181955.1
Coordinates 355159..355452 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNX43_RS01635 (350738) 350738..352171 + 1434 WP_002920564.1 glycogen synthase GlgA -
NNX43_RS01640 (352189) 352189..354636 + 2448 WP_002920561.1 glycogen phosphorylase -
NNX43_RS01645 (354812) 354812..355159 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NNX43_RS01650 (355159) 355159..355452 + 294 WP_040181955.1 helix-turn-helix transcriptional regulator Antitoxin
NNX43_RS01655 (355522) 355522..357030 - 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
NNX43_RS01660 (357235) 357235..357564 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NNX43_RS01665 (357615) 357615..358445 + 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
NNX43_RS01670 (358495) 358495..359253 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T252832 WP_016529833.1 NZ_CP101877:354812-355159 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10539.30 Da        Isoelectric Point: 10.1464

>AT252832 WP_040181955.1 NZ_CP101877:355159-355452 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure

References