Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 105604..105858 Replicon plasmid pLP5-1-106kb
Accession NZ_CP101867
Organism Escherichia coli strain LP5-1

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag NPX81_RS22835 Protein ID WP_001312851.1
Coordinates 105709..105858 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 105604..105665 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX81_RS22820 (103557) 103557..104300 + 744 WP_039002216.1 conjugal transfer pilus acetylase TraX -
NPX81_RS22825 (104355) 104355..104915 + 561 WP_000139310.1 fertility inhibition protein FinO -
NPX81_RS22830 (105050) 105050..105262 + 213 WP_001541896.1 ANR family transcriptional regulator -
- (105604) 105604..105665 - 62 NuclAT_1 - Antitoxin
- (105604) 105604..105665 - 62 NuclAT_1 - Antitoxin
- (105604) 105604..105665 - 62 NuclAT_1 - Antitoxin
- (105604) 105604..105665 - 62 NuclAT_1 - Antitoxin
NPX81_RS22835 (105709) 105709..105858 + 150 WP_001312851.1 Hok/Gef family protein Toxin
NPX81_RS22840 (106126) 106126..106383 + 258 WP_001541895.1 replication regulatory protein RepA -
NPX81_RS22845 (106486) 106486..106669 + 184 Protein_130 protein CopA/IncA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mef(B) / aph(3')-Ia - 1..106681 106681


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T252828 WP_001312851.1 NZ_CP101867:105709-105858 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

Antitoxin


Download         Length: 62 bp

>AT252828 NZ_CP101867:c105665-105604 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References