Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4382679..4383281 Replicon chromosome
Accession NZ_CP101866
Organism Escherichia coli strain LP5-1

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NPX81_RS21275 Protein ID WP_000897305.1
Coordinates 4382970..4383281 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NPX81_RS21270 Protein ID WP_000356397.1
Coordinates 4382679..4382969 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX81_RS21245 (4378607) 4378607..4379509 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NPX81_RS21250 (4379506) 4379506..4380141 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NPX81_RS21255 (4380138) 4380138..4381067 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NPX81_RS21260 (4381396) 4381396..4381638 - 243 WP_024199136.1 CopG family transcriptional regulator -
NPX81_RS21265 (4381857) 4381857..4382075 - 219 WP_001295676.1 CopG family transcriptional regulator -
NPX81_RS21270 (4382679) 4382679..4382969 - 291 WP_000356397.1 NadS family protein Antitoxin
NPX81_RS21275 (4382970) 4382970..4383281 - 312 WP_000897305.1 hypothetical protein Toxin
NPX81_RS21280 (4383510) 4383510..4384418 + 909 WP_001491417.1 alpha/beta hydrolase -
NPX81_RS21285 (4384587) 4384587..4385501 - 915 Protein_4155 transposase -
NPX81_RS21290 (4385514) 4385514..4386401 - 888 Protein_4156 hypothetical protein -
NPX81_RS21295 (4386811) 4386811..4387752 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NPX81_RS21300 (4387797) 4387797..4388234 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T252823 WP_000897305.1 NZ_CP101866:c4383281-4382970 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT252823 WP_000356397.1 NZ_CP101866:c4382969-4382679 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References