Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3841044..3841302 Replicon chromosome
Accession NZ_CP101866
Organism Escherichia coli strain LP5-1

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NPX81_RS18720 Protein ID WP_000809168.1
Coordinates 3841150..3841302 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3841044..3841101 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX81_RS18705 3837436..3838395 + 960 WP_000871692.1 hypothetical protein -
NPX81_RS18710 3838433..3839332 - 900 WP_001300855.1 transcriptional activator NhaR -
NPX81_RS18715 3839398..3840564 - 1167 WP_000681368.1 Na+/H+ antiporter NhaA -
- 3841044..3841101 - 58 - - Antitoxin
NPX81_RS18720 3841150..3841302 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
NPX81_RS18725 3841406..3842536 - 1131 WP_001118464.1 molecular chaperone DnaJ -
NPX81_RS18730 3842625..3844541 - 1917 WP_000516135.1 molecular chaperone DnaK -
NPX81_RS18735 3844918..3845322 + 405 WP_000843568.1 DUF2541 family protein -
NPX81_RS18740 3845348..3846061 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T252820 WP_000809168.1 NZ_CP101866:3841150-3841302 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT252820 NZ_CP101866:c3841101-3841044 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References