Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4166744..4167285 Replicon chromosome
Accession NZ_CP101858
Organism Escherichia coli strain LP50-1

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag NPX80_RS20155 Protein ID WP_000615976.1
Coordinates 4166744..4167022 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NPX80_RS20160 Protein ID WP_000729704.1
Coordinates 4167025..4167285 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX80_RS20140 (4164326) 4164326..4164904 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
NPX80_RS20145 (4165110) 4165110..4165877 + 768 WP_000333380.1 class II glutamine amidotransferase -
NPX80_RS20150 (4165848) 4165848..4166588 - 741 WP_063100007.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NPX80_RS20155 (4166744) 4166744..4167022 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NPX80_RS20160 (4167025) 4167025..4167285 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NPX80_RS20165 (4167471) 4167471..4168244 + 774 WP_000543895.1 C40 family peptidase -
NPX80_RS20170 (4168301) 4168301..4168657 - 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
NPX80_RS20175 (4168650) 4168650..4168928 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NPX80_RS20180 (4169033) 4169033..4170745 - 1713 Protein_3936 flagellar biosynthesis protein FlhA -
NPX80_RS20185 (4170717) 4170717..4171502 + 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 4157381..4168928 11547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T252791 WP_000615976.1 NZ_CP101858:c4167022-4166744 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT252791 WP_000729704.1 NZ_CP101858:c4167285-4167025 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References