252781

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1163321..1163823 Replicon chromosome
Accession NZ_CP101858
Organism Escherichia coli strain LP50-1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NPX80_RS05745 Protein ID WP_000767829.1
Coordinates 1163321..1163575 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NPX80_RS05750 Protein ID WP_001259255.1
Coordinates 1163572..1163823 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX80_RS05715 (1158336) 1158336..1158563 - 228 WP_000234896.1 sulfurtransferase TusA -
NPX80_RS05720 (1158577) 1158577..1159635 - 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
NPX80_RS05725 (1159814) 1159814..1161172 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NPX80_RS05730 (1161162) 1161162..1161224 - 63 WP_010723108.1 membrane protein YoeI -
NPX80_RS05735 (1161439) 1161439..1162368 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NPX80_RS05740 (1162414) 1162414..1163238 - 825 WP_000754737.1 SDR family oxidoreductase -
NPX80_RS05745 (1163321) 1163321..1163575 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NPX80_RS05750 (1163572) 1163572..1163823 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NPX80_RS05755 (1164106) 1164106..1164156 + 51 WP_001364200.1 his operon leader peptide -
NPX80_RS05760 (1164302) 1164302..1165201 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
NPX80_RS05765 (1165207) 1165207..1166505 + 1299 WP_000009595.1 histidinol dehydrogenase -
NPX80_RS05770 (1166508) 1166508..1167578 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
NPX80_RS05775 (1167578) 1167578..1168645 + 1068 WP_000080135.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T252781 WP_000767829.1 NZ_CP101858:c1163575-1163321 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT252781 WP_001259255.1 NZ_CP101858:c1163823-1163572 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References