Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 276888..277407 Replicon chromosome
Accession NZ_CP101844
Organism Streptococcus suis strain 2018WUSS151

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8M4E9
Locus tag NOV99_RS01485 Protein ID WP_002939009.1
Coordinates 277150..277407 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag NOV99_RS01480 Protein ID WP_240016561.1
Coordinates 276888..277148 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV99_RS01445 (NOV99_01445) 272194..273006 + 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
NOV99_RS01450 (NOV99_01450) 273026..274021 + 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
NOV99_RS01455 (NOV99_01455) 274189..274326 + 138 WP_002939016.1 50S ribosomal protein L34 -
NOV99_RS01460 (NOV99_01460) 274435..275217 + 783 WP_002939015.1 TatD family hydrolase -
NOV99_RS01465 (NOV99_01465) 275180..275770 + 591 WP_002939014.1 ribonuclease M5 -
NOV99_RS01470 (NOV99_01470) 275763..276353 + 591 WP_240016560.1 hypothetical protein -
NOV99_RS01475 (NOV99_01475) 276357..276812 + 456 WP_002939012.1 8-oxo-dGTP diphosphatase -
NOV99_RS01480 (NOV99_01480) 276888..277148 + 261 WP_240016561.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NOV99_RS01485 (NOV99_01485) 277150..277407 + 258 WP_002939009.1 Txe/YoeB family addiction module toxin Toxin
NOV99_RS01490 (NOV99_01490) 277421..277951 + 531 WP_002939008.1 DUF1697 domain-containing protein -
NOV99_RS01495 (NOV99_01495) 277971..278843 + 873 WP_002939007.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NOV99_RS01500 (NOV99_01500) 279046..280776 + 1731 WP_240020608.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10321.83 Da        Isoelectric Point: 7.3119

>T252759 WP_002939009.1 NZ_CP101844:277150-277407 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEVDKLYILSL
KDHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.41 Da        Isoelectric Point: 6.4707

>AT252759 WP_240016561.1 NZ_CP101844:276888-277148 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTKER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8M4E9

Antitoxin

Source ID Structure

References