Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 660450..660966 Replicon chromosome
Accession NZ_CP101831
Organism Lacticaseibacillus paracasei strain SMN-LBK

Toxin (Protein)


Gene name yafQ Uniprot ID A0A243Q0H7
Locus tag NPC72_RS03220 Protein ID WP_003573774.1
Coordinates 660685..660966 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag NPC72_RS03215 Protein ID WP_016363783.1
Coordinates 660450..660692 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPC72_RS03200 (NPC72_03200) 655904..658075 - 2172 WP_003607130.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
NPC72_RS03205 (NPC72_03205) 658247..659236 + 990 WP_003586769.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
NPC72_RS03210 (NPC72_03210) 659233..659718 + 486 WP_003586772.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
NPC72_RS03215 (NPC72_03215) 660450..660692 + 243 WP_016363783.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NPC72_RS03220 (NPC72_03220) 660685..660966 + 282 WP_003573774.1 type II toxin-antitoxin system YafQ family toxin Toxin
NPC72_RS03225 (NPC72_03225) 661166..661564 + 399 WP_003586778.1 DUF1722 domain-containing protein -
NPC72_RS03230 (NPC72_03230) 661809..662918 - 1110 WP_003607129.1 hypothetical protein -
NPC72_RS03235 (NPC72_03235) 662920..664350 - 1431 WP_003607128.1 hypothetical protein -
NPC72_RS03240 (NPC72_03240) 664540..665223 + 684 WP_003586785.1 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 556832..689532 132700
- flank IS/Tn - - 654323..655738 1415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-93)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-62)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11371.98 Da        Isoelectric Point: 9.5081

>T252738 WP_003573774.1 NZ_CP101831:660685-660966 [Lacticaseibacillus paracasei]
MNKFVYKPAFERQFKKHYKTILKGGRYKKEDFEAVYHKLLRDEPLDPHYNDHALVNRKPERDLHIKPDWLLIYKYDGEFV
RFIDTGSHSDLFN

Download         Length: 282 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9217.44 Da        Isoelectric Point: 5.1548

>AT252738 WP_016363783.1 NZ_CP101831:660450-660692 [Lacticaseibacillus paracasei]
MTSQVHFRMSEKEKKDFEIVLSRVGLTPGEAFRIFAKKSIEAGGIPFEVSQPNTRLKKAIRSQDYVEFNDPEEGLDWLNE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A243Q0H7

Antitoxin

Source ID Structure

References