Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3872652..3873249 Replicon chromosome
Accession NZ_CP101790
Organism Klebsiella pneumoniae strain hvKP859

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag NPJ86_RS18950 Protein ID WP_004142563.1
Coordinates 3872932..3873249 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag NPJ86_RS18945 Protein ID WP_004142561.1
Coordinates 3872652..3872939 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ86_RS18915 (NPJ86_18915) 3868732..3868980 + 249 WP_002893037.1 DUF1158 domain-containing protein -
NPJ86_RS18920 (NPJ86_18920) 3868998..3869339 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
NPJ86_RS18925 (NPJ86_18925) 3869370..3870485 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
NPJ86_RS18930 (NPJ86_18930) 3870665..3871246 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
NPJ86_RS18935 (NPJ86_18935) 3871246..3871614 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
NPJ86_RS18940 (NPJ86_18940) 3871734..3872387 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
NPJ86_RS18945 (NPJ86_18945) 3872652..3872939 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
NPJ86_RS18950 (NPJ86_18950) 3872932..3873249 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NPJ86_RS18955 (NPJ86_18955) 3873434..3874477 - 1044 WP_020802450.1 DUF2157 domain-containing protein -
NPJ86_RS18960 (NPJ86_18960) 3875147..3876013 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
NPJ86_RS18965 (NPJ86_18965) 3876122..3877549 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T252726 WP_004142563.1 NZ_CP101790:c3873249-3872932 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT252726 WP_004142561.1 NZ_CP101790:c3872939-3872652 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References