Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 324846..325432 Replicon chromosome
Accession NZ_CP101790
Organism Klebsiella pneumoniae strain hvKP859

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag NPJ86_RS01505 Protein ID WP_002920800.1
Coordinates 325064..325432 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag NPJ86_RS01500 Protein ID WP_004174006.1
Coordinates 324846..325067 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ86_RS01480 (NPJ86_01480) 321003..321929 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NPJ86_RS01485 (NPJ86_01485) 321926..323203 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
NPJ86_RS01490 (NPJ86_01490) 323200..323967 + 768 WP_073557610.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NPJ86_RS01495 (NPJ86_01495) 323969..324682 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
NPJ86_RS01500 (NPJ86_01500) 324846..325067 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NPJ86_RS01505 (NPJ86_01505) 325064..325432 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NPJ86_RS01510 (NPJ86_01510) 325705..327021 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
NPJ86_RS01515 (NPJ86_01515) 327128..328015 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
NPJ86_RS01520 (NPJ86_01520) 328012..328857 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
NPJ86_RS01525 (NPJ86_01525) 328859..329929 + 1071 WP_016946109.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 321926..330666 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T252718 WP_002920800.1 NZ_CP101790:325064-325432 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT252718 WP_004174006.1 NZ_CP101790:324846-325067 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References