Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 745030..745805 Replicon chromosome
Accession NZ_CP101784
Organism Klebsiella pneumoniae strain hvKP841

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag NPJ85_RS03725 Protein ID WP_004150910.1
Coordinates 745320..745805 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NPJ85_RS03720 Protein ID WP_004150912.1
Coordinates 745030..745323 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ85_RS03700 (NPJ85_03700) 740238..740840 - 603 WP_062954968.1 short chain dehydrogenase -
NPJ85_RS03705 (NPJ85_03705) 740938..741849 + 912 WP_004188550.1 LysR family transcriptional regulator -
NPJ85_RS03710 (NPJ85_03710) 741850..742998 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
NPJ85_RS03715 (NPJ85_03715) 743009..744385 - 1377 WP_004217775.1 cystathionine beta-synthase -
NPJ85_RS03720 (NPJ85_03720) 745030..745323 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NPJ85_RS03725 (NPJ85_03725) 745320..745805 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
NPJ85_RS03730 (NPJ85_03730) 746509..747102 + 594 WP_004188553.1 hypothetical protein -
NPJ85_RS03735 (NPJ85_03735) 747199..747415 + 217 Protein_734 transposase -
NPJ85_RS03740 (NPJ85_03740) 748021..748893 + 873 WP_004188557.1 ParA family protein -
NPJ85_RS03745 (NPJ85_03745) 748893..749276 + 384 WP_004150906.1 hypothetical protein -
NPJ85_RS03750 (NPJ85_03750) 749269..750636 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 747199..747351 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T252694 WP_004150910.1 NZ_CP101784:745320-745805 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT252694 WP_004150912.1 NZ_CP101784:745030-745323 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References