Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 581226..581879 | Replicon | chromosome |
Accession | NC_015567 | ||
Organism | Serratia plymuthica AS9 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A7U3YYL4 |
Locus tag | SERAS9_RS02685 | Protein ID | WP_013811355.1 |
Coordinates | 581226..581576 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | SERAS9_RS02690 | Protein ID | WP_013811356.1 |
Coordinates | 581580..581879 (+) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SERAS9_RS02660 | 576705..577796 | + | 1092 | WP_004949798.1 | dimethyl sulfone monooxygenase SfnG | - |
SERAS9_RS02665 | 577798..578499 | - | 702 | WP_006323392.1 | trehalose-6-phosphate synthase | - |
SERAS9_RS02670 | 578514..579053 | - | 540 | WP_013811352.1 | GNAT family N-acetyltransferase | - |
SERAS9_RS02675 | 579111..580490 | - | 1380 | WP_013811353.1 | glutamine synthetase family protein | - |
SERAS9_RS02680 | 580746..581060 | + | 315 | WP_013811354.1 | hypothetical protein | - |
SERAS9_RS02685 | 581226..581576 | + | 351 | WP_013811355.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
SERAS9_RS02690 | 581580..581879 | + | 300 | WP_013811356.1 | helix-turn-helix transcriptional regulator | Antitoxin |
SERAS9_RS02695 | 581972..583048 | - | 1077 | WP_013811357.1 | YncE family protein | - |
SERAS9_RS02700 | 583334..584602 | - | 1269 | WP_013811358.1 | multidrug effflux MFS transporter | - |
SERAS9_RS02705 | 584602..585825 | - | 1224 | WP_013811359.1 | cytochrome P450 | - |
SERAS9_RS02710 | 585840..586097 | - | 258 | WP_013811360.1 | acyl carrier protein | - |
SERAS9_RS02715 | 586144..586695 | - | 552 | WP_013811361.1 | NAD(P)H-dependent oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13456.56 Da Isoelectric Point: 8.5393
>T25269 WP_013811355.1 NC_015567:581226-581576 [Serratia plymuthica AS9]
MWTVITTEEFDRWFAVQDELTQEKVLAALVLLERSGPNLSRPFVDSLRGSQHPNMKELRVQHKGRPIRAFFAFDSLRQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQHLMCNFKE
MWTVITTEEFDRWFAVQDELTQEKVLAALVLLERSGPNLSRPFVDSLRGSQHPNMKELRVQHKGRPIRAFFAFDSLRQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQHLMCNFKE
Download Length: 351 bp
>T25269 NC_015567:581226-581576 [Serratia plymuthica AS9]
ATGTGGACTGTAATAACAACGGAAGAGTTTGATCGGTGGTTTGCGGTGCAGGATGAACTTACTCAGGAGAAAGTGCTGGC
TGCATTAGTATTGCTTGAGCGGAGTGGCCCCAACCTCTCACGTCCTTTTGTAGACTCGTTGAGAGGGTCACAGCACCCTA
ATATGAAAGAACTGCGGGTTCAGCATAAAGGGCGGCCGATTCGCGCTTTTTTTGCCTTTGACTCACTACGTCAGGCTATT
GTTTTGTGTGCCGGCGATAAGACTGGTAACGAGAAGCGGTTTTACAAAGTCATGCTGCCTATTGCGGATGCGCAGTTTAC
CCAGCATTTGATGTGTAATTTTAAGGAGTAG
ATGTGGACTGTAATAACAACGGAAGAGTTTGATCGGTGGTTTGCGGTGCAGGATGAACTTACTCAGGAGAAAGTGCTGGC
TGCATTAGTATTGCTTGAGCGGAGTGGCCCCAACCTCTCACGTCCTTTTGTAGACTCGTTGAGAGGGTCACAGCACCCTA
ATATGAAAGAACTGCGGGTTCAGCATAAAGGGCGGCCGATTCGCGCTTTTTTTGCCTTTGACTCACTACGTCAGGCTATT
GTTTTGTGTGCCGGCGATAAGACTGGTAACGAGAAGCGGTTTTACAAAGTCATGCTGCCTATTGCGGATGCGCAGTTTAC
CCAGCATTTGATGTGTAATTTTAAGGAGTAG
Antitoxin
Download Length: 100 a.a. Molecular weight: 11183.85 Da Isoelectric Point: 5.1667
>AT25269 WP_013811356.1 NC_015567:581580-581879 [Serratia plymuthica AS9]
MGTLKDMLASRTPESLQRIEEMAQEMWLEARLYQLREALNISQQELANNLGISQPSVAAIEQRGNELKISTLKRYVEAMG
GTLRLDVELPDGKHVGFRV
MGTLKDMLASRTPESLQRIEEMAQEMWLEARLYQLREALNISQQELANNLGISQPSVAAIEQRGNELKISTLKRYVEAMG
GTLRLDVELPDGKHVGFRV
Download Length: 300 bp
>AT25269 NC_015567:581580-581879 [Serratia plymuthica AS9]
ATGGGTACTTTAAAAGACATGCTAGCCTCGCGTACCCCGGAGAGTCTGCAACGAATCGAAGAAATGGCGCAAGAGATGTG
GCTGGAAGCACGGTTGTACCAATTGCGTGAGGCGCTGAATATCTCACAGCAGGAACTGGCGAATAATCTGGGTATCTCCC
AGCCTTCCGTCGCGGCGATAGAGCAGCGTGGCAATGAGCTGAAGATATCGACATTGAAGCGCTATGTGGAAGCGATGGGC
GGAACGTTGCGGCTGGATGTCGAACTGCCGGACGGCAAGCACGTTGGATTTAGAGTTTAA
ATGGGTACTTTAAAAGACATGCTAGCCTCGCGTACCCCGGAGAGTCTGCAACGAATCGAAGAAATGGCGCAAGAGATGTG
GCTGGAAGCACGGTTGTACCAATTGCGTGAGGCGCTGAATATCTCACAGCAGGAACTGGCGAATAATCTGGGTATCTCCC
AGCCTTCCGTCGCGGCGATAGAGCAGCGTGGCAATGAGCTGAAGATATCGACATTGAAGCGCTATGTGGAAGCGATGGGC
GGAACGTTGCGGCTGGATGTCGAACTGCCGGACGGCAAGCACGTTGGATTTAGAGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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