Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 581226..581879 Replicon chromosome
Accession NC_015567
Organism Serratia plymuthica AS9

Toxin (Protein)


Gene name higB Uniprot ID A0A7U3YYL4
Locus tag SERAS9_RS02685 Protein ID WP_013811355.1
Coordinates 581226..581576 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SERAS9_RS02690 Protein ID WP_013811356.1
Coordinates 581580..581879 (+) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS9_RS02660 576705..577796 + 1092 WP_004949798.1 dimethyl sulfone monooxygenase SfnG -
SERAS9_RS02665 577798..578499 - 702 WP_006323392.1 trehalose-6-phosphate synthase -
SERAS9_RS02670 578514..579053 - 540 WP_013811352.1 GNAT family N-acetyltransferase -
SERAS9_RS02675 579111..580490 - 1380 WP_013811353.1 glutamine synthetase family protein -
SERAS9_RS02680 580746..581060 + 315 WP_013811354.1 hypothetical protein -
SERAS9_RS02685 581226..581576 + 351 WP_013811355.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SERAS9_RS02690 581580..581879 + 300 WP_013811356.1 helix-turn-helix transcriptional regulator Antitoxin
SERAS9_RS02695 581972..583048 - 1077 WP_013811357.1 YncE family protein -
SERAS9_RS02700 583334..584602 - 1269 WP_013811358.1 multidrug effflux MFS transporter -
SERAS9_RS02705 584602..585825 - 1224 WP_013811359.1 cytochrome P450 -
SERAS9_RS02710 585840..586097 - 258 WP_013811360.1 acyl carrier protein -
SERAS9_RS02715 586144..586695 - 552 WP_013811361.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-106)

Antitoxin

(31-83)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 13456.56 Da        Isoelectric Point: 8.5393

>T25269 WP_013811355.1 NC_015567:581226-581576 [Serratia plymuthica AS9]
MWTVITTEEFDRWFAVQDELTQEKVLAALVLLERSGPNLSRPFVDSLRGSQHPNMKELRVQHKGRPIRAFFAFDSLRQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQHLMCNFKE

Download         Length: 351 bp

>T25269 NC_015567:581226-581576 [Serratia plymuthica AS9]
ATGTGGACTGTAATAACAACGGAAGAGTTTGATCGGTGGTTTGCGGTGCAGGATGAACTTACTCAGGAGAAAGTGCTGGC
TGCATTAGTATTGCTTGAGCGGAGTGGCCCCAACCTCTCACGTCCTTTTGTAGACTCGTTGAGAGGGTCACAGCACCCTA
ATATGAAAGAACTGCGGGTTCAGCATAAAGGGCGGCCGATTCGCGCTTTTTTTGCCTTTGACTCACTACGTCAGGCTATT
GTTTTGTGTGCCGGCGATAAGACTGGTAACGAGAAGCGGTTTTACAAAGTCATGCTGCCTATTGCGGATGCGCAGTTTAC
CCAGCATTTGATGTGTAATTTTAAGGAGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11183.85 Da        Isoelectric Point: 5.1667

>AT25269 WP_013811356.1 NC_015567:581580-581879 [Serratia plymuthica AS9]
MGTLKDMLASRTPESLQRIEEMAQEMWLEARLYQLREALNISQQELANNLGISQPSVAAIEQRGNELKISTLKRYVEAMG
GTLRLDVELPDGKHVGFRV

Download         Length: 300 bp

>AT25269 NC_015567:581580-581879 [Serratia plymuthica AS9]
ATGGGTACTTTAAAAGACATGCTAGCCTCGCGTACCCCGGAGAGTCTGCAACGAATCGAAGAAATGGCGCAAGAGATGTG
GCTGGAAGCACGGTTGTACCAATTGCGTGAGGCGCTGAATATCTCACAGCAGGAACTGGCGAATAATCTGGGTATCTCCC
AGCCTTCCGTCGCGGCGATAGAGCAGCGTGGCAATGAGCTGAAGATATCGACATTGAAGCGCTATGTGGAAGCGATGGGC
GGAACGTTGCGGCTGGATGTCGAACTGCCGGACGGCAAGCACGTTGGATTTAGAGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U3YYL4


Antitoxin

Source ID Structure

References