Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 329100..329686 Replicon chromosome
Accession NZ_CP101770
Organism Klebsiella pneumoniae strain hvKP323

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag NO368_RS01535 Protein ID WP_002920800.1
Coordinates 329318..329686 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag NO368_RS01530 Protein ID WP_002920802.1
Coordinates 329100..329321 (+) Length 74 a.a.

Genomic Context


NO368_RS01510NO368_RS01515NO368_RS01520NO368_RS01525NO368_RS01530NO368_RS01535NO368_RS01540NO368_RS01545NO368_RS01550NO368_RS01555
Location: 325257..326183 (927 bp)
Type: Others
Protein ID: WP_002920807.1
Location: 326180..327457 (1278 bp)
Type: Others
Protein ID: WP_002920806.1
Location: 327454..328221 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Location: 328223..328936 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Location: 329100..329321 (222 bp)
Type: Antitoxin
Protein ID: WP_002920802.1
Location: 329318..329686 (369 bp)
Type: Toxin
Protein ID: WP_002920800.1
Location: 329959..331275 (1317 bp)
Type: Others
Protein ID: WP_002920796.1
Location: 331382..332269 (888 bp)
Type: Others
Protein ID: WP_002920792.1
Location: 332266..333111 (846 bp)
Type: Others
Protein ID: WP_002920789.1
Location: 333113..334183 (1071 bp)
Type: Others
Protein ID: WP_002920787.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NO368_RS01510 (NO368_01510)325257..326183+927WP_002920807.1high-affinity branched-chain amino acid ABC transporter permease LivH-
NO368_RS01515 (NO368_01515)326180..327457+1278WP_002920806.1branched chain amino acid ABC transporter permease LivM-
NO368_RS01520 (NO368_01520)327454..328221+768WP_002920803.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
NO368_RS01525 (NO368_01525)328223..328936+714WP_004145133.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
NO368_RS01530 (NO368_01530)329100..329321+222WP_002920802.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
NO368_RS01535 (NO368_01535)329318..329686+369WP_002920800.1type II toxin-antitoxin system death-on-curing family toxinToxin
NO368_RS01540 (NO368_01540)329959..331275+1317WP_002920796.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
NO368_RS01545 (NO368_01545)331382..332269+888WP_002920792.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
NO368_RS01550 (NO368_01550)332266..333111+846WP_002920789.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
NO368_RS01555 (NO368_01555)333113..334183+1071WP_002920787.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--326180..3349208740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-86)

Antitoxin

(1-49)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T252641 WP_002920800.1 NZ_CP101770:329318-329686 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp


Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT252641 WP_002920802.1 NZ_CP101770:329100-329321 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GUD1


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GZM4

References