Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3096237..3096850 Replicon chromosome
Accession NZ_CP101752
Organism Pseudomonas citronellolis strain C12

Toxin (Protein)


Gene name higB Uniprot ID A0A4Z0IS23
Locus tag NOX82_RS13955 Protein ID WP_074979656.1
Coordinates 3096237..3096533 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NOX82_RS13960 Protein ID WP_024128404.1
Coordinates 3096542..3096850 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOX82_RS13945 (NOX82_13945) 3093448..3094614 - 1167 WP_074979652.1 efflux RND transporter periplasmic adaptor subunit -
NOX82_RS13950 (NOX82_13950) 3094611..3096014 - 1404 WP_256515090.1 efflux transporter outer membrane subunit -
NOX82_RS13955 (NOX82_13955) 3096237..3096533 + 297 WP_074979656.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOX82_RS13960 (NOX82_13960) 3096542..3096850 + 309 WP_024128404.1 HigA family addiction module antitoxin Antitoxin
NOX82_RS13965 (NOX82_13965) 3097454..3098137 - 684 WP_074979659.1 response regulator transcription factor -
NOX82_RS13970 (NOX82_13970) 3098242..3098931 + 690 WP_074979712.1 response regulator transcription factor -
NOX82_RS13975 (NOX82_13975) 3098909..3100291 + 1383 WP_256515091.1 ATP-binding protein -
NOX82_RS13980 (NOX82_13980) 3100562..3101128 - 567 WP_256515092.1 flavin reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11834.32 Da        Isoelectric Point: 8.5983

>T252601 WP_074979656.1 NZ_CP101752:3096237-3096533 [Pseudomonas citronellolis]
MIGSFREAWLEAFFVRDRMPRQIPADIQERLFRKLQMLDDATTDADLRSPPSNHFERLQGRLRAYHSIRVNRQWRLVFHW
DGEKGEASDVYLDNHSYR

Download         Length: 297 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11471.20 Da        Isoelectric Point: 11.1591

>AT252601 WP_024128404.1 NZ_CP101752:3096542-3096850 [Pseudomonas citronellolis]
VIITERKPVSVGEVLSSEFLDPLGLTQGRLAEAMGVQRKLVNELCNDRRAVTADTALMLARVFGNSAEFWLNLQRRNDLW
AALNSPERRARIERARPLNRAA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z0IS23

Antitoxin

Source ID Structure

References