Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE(toxin)
Location 2952..3601 Replicon plasmid unnamed5
Accession NZ_CP101748
Organism Comamonas sp. C11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NOX35_RS28455 Protein ID WP_256497121.1
Coordinates 2952..3290 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NOX35_RS28460 Protein ID WP_256497122.1
Coordinates 3287..3601 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOX35_RS28445 (NOX35_28445) 1..975 + 975 WP_256497119.1 tripartite tricarboxylate transporter substrate binding protein -
NOX35_RS28450 (NOX35_28450) 987..2537 + 1551 WP_256497120.1 AMP-binding protein -
NOX35_RS28455 (NOX35_28455) 2952..3290 + 339 WP_256497121.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOX35_RS28460 (NOX35_28460) 3287..3601 + 315 WP_256497122.1 helix-turn-helix domain-containing protein Antitoxin
NOX35_RS28465 (NOX35_28465) 3699..4385 - 687 WP_256497123.1 50S ribosome-binding GTPase -
NOX35_RS28470 (NOX35_28470) 4388..5365 - 978 WP_256497124.1 50S ribosome-binding GTPase -
NOX35_RS28475 (NOX35_28475) 5603..6691 + 1089 WP_256497125.1 IS5 family transposase -
NOX35_RS28480 (NOX35_28480) 6801..7526 - 726 Protein_7 IS30 family transposase -
NOX35_RS28485 (NOX35_28485) 7571..7681 - 111 Protein_8 IS5/IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19871 19871


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-101)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13090.93 Da        Isoelectric Point: 9.7324

>T252590 WP_256497121.1 NZ_CP101748:2952-3290 [Comamonas sp. C11]
MKAVFVELPAFERNRATYLSDDEFKEFQERLLKNPEAGDMIEGTGGLRKVRHGDPRRGKGTRGGLRVIYYWWSGGPQFWL
FTLYDKDELENLTPKQKATLKQLLKNELEARQ

Download         Length: 339 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11855.63 Da        Isoelectric Point: 10.3044

>AT252590 WP_256497122.1 NZ_CP101748:3287-3601 [Comamonas sp. C11]
MTKRDLFAELTEGFDALASAREGKRTLRTHEIEIKPEVSITSEELKSIRERLKLSRTVFASYLRTKPRTLENWEQGRAAP
NAQAALLIRLVEKYPDTVSRLAAV

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References