Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 124447..124868 Replicon plasmid pVir_150040X1B1
Accession NZ_CP101728
Organism Klebsiella pneumoniae strain 150040X1B1

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag NPN21_RS28530 Protein ID WP_096937776.1
Coordinates 124447..124572 (-) Length 42 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 124670..124868 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPN21_RS28490 (119512) 119512..119727 - 216 WP_001352842.1 conjugal transfer relaxosome protein TraY -
NPN21_RS28495 (119863) 119863..120510 - 648 WP_000332520.1 conjugal transfer transcriptional regulator TraJ -
NPN21_RS28500 (120702) 120702..121085 - 384 WP_001063020.1 conjugal transfer relaxosome DNA-binding protein TraM -
NPN21_RS28505 (121437) 121437..122027 + 591 WP_166494936.1 transglycosylase SLT domain-containing protein -
NPN21_RS28510 (122322) 122322..123143 - 822 WP_001234475.1 DUF932 domain-containing protein -
NPN21_RS28515 (123262) 123262..123549 - 288 WP_000107546.1 hypothetical protein -
NPN21_RS28520 (123574) 123574..123780 - 207 WP_000547965.1 hypothetical protein -
NPN21_RS28525 (123850) 123850..124146 + 297 Protein_128 hypothetical protein -
NPN21_RS28530 (124447) 124447..124572 - 126 WP_096937776.1 type I toxin-antitoxin system Hok family toxin Toxin
NPN21_RS28535 (124514) 124514..124663 - 150 Protein_130 DUF5431 family protein -
- (124670) 124670..124868 - 199 NuclAT_0 - Antitoxin
- (124670) 124670..124868 - 199 NuclAT_0 - Antitoxin
- (124670) 124670..124868 - 199 NuclAT_0 - Antitoxin
- (124670) 124670..124868 - 199 NuclAT_0 - Antitoxin
NPN21_RS28540 (124837) 124837..125599 - 763 Protein_131 plasmid SOS inhibition protein A -
NPN21_RS28545 (125596) 125596..126030 - 435 WP_000845928.1 conjugation system SOS inhibitor PsiB -
NPN21_RS28550 (126085) 126085..128043 - 1959 WP_029487628.1 ParB/RepB/Spo0J family partition protein -
NPN21_RS28555 (128109) 128109..128342 - 234 WP_000005990.1 DUF905 family protein -
NPN21_RS28560 (128399) 128399..128938 - 540 WP_000290801.1 single-stranded DNA-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / sitABCD iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA 1..172348 172348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4806.72 Da        Isoelectric Point: 8.4890

>T252575 WP_096937776.1 NZ_CP101728:c124572-124447 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK

Download         Length: 126 bp


Antitoxin


Download         Length: 199 bp

>AT252575 NZ_CP101728:c124868-124670 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References