Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 124447..124868 | Replicon | plasmid pVir_150040X1B1 |
Accession | NZ_CP101728 | ||
Organism | Klebsiella pneumoniae strain 150040X1B1 |
Toxin (Protein)
Gene name | hok | Uniprot ID | - |
Locus tag | NPN21_RS28530 | Protein ID | WP_096937776.1 |
Coordinates | 124447..124572 (-) | Length | 42 a.a. |
Antitoxin (RNA)
Gene name | srnC | ||
Locus tag | - | ||
Coordinates | 124670..124868 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NPN21_RS28490 (119512) | 119512..119727 | - | 216 | WP_001352842.1 | conjugal transfer relaxosome protein TraY | - |
NPN21_RS28495 (119863) | 119863..120510 | - | 648 | WP_000332520.1 | conjugal transfer transcriptional regulator TraJ | - |
NPN21_RS28500 (120702) | 120702..121085 | - | 384 | WP_001063020.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
NPN21_RS28505 (121437) | 121437..122027 | + | 591 | WP_166494936.1 | transglycosylase SLT domain-containing protein | - |
NPN21_RS28510 (122322) | 122322..123143 | - | 822 | WP_001234475.1 | DUF932 domain-containing protein | - |
NPN21_RS28515 (123262) | 123262..123549 | - | 288 | WP_000107546.1 | hypothetical protein | - |
NPN21_RS28520 (123574) | 123574..123780 | - | 207 | WP_000547965.1 | hypothetical protein | - |
NPN21_RS28525 (123850) | 123850..124146 | + | 297 | Protein_128 | hypothetical protein | - |
NPN21_RS28530 (124447) | 124447..124572 | - | 126 | WP_096937776.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
NPN21_RS28535 (124514) | 124514..124663 | - | 150 | Protein_130 | DUF5431 family protein | - |
- (124670) | 124670..124868 | - | 199 | NuclAT_0 | - | Antitoxin |
- (124670) | 124670..124868 | - | 199 | NuclAT_0 | - | Antitoxin |
- (124670) | 124670..124868 | - | 199 | NuclAT_0 | - | Antitoxin |
- (124670) | 124670..124868 | - | 199 | NuclAT_0 | - | Antitoxin |
NPN21_RS28540 (124837) | 124837..125599 | - | 763 | Protein_131 | plasmid SOS inhibition protein A | - |
NPN21_RS28545 (125596) | 125596..126030 | - | 435 | WP_000845928.1 | conjugation system SOS inhibitor PsiB | - |
NPN21_RS28550 (126085) | 126085..128043 | - | 1959 | WP_029487628.1 | ParB/RepB/Spo0J family partition protein | - |
NPN21_RS28555 (128109) | 128109..128342 | - | 234 | WP_000005990.1 | DUF905 family protein | - |
NPN21_RS28560 (128399) | 128399..128938 | - | 540 | WP_000290801.1 | single-stranded DNA-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | tet(A) / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / sitABCD | iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA | 1..172348 | 172348 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4806.72 Da Isoelectric Point: 8.4890
>T252575 WP_096937776.1 NZ_CP101728:c124572-124447 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK
Download Length: 126 bp
Antitoxin
Download Length: 199 bp
>AT252575 NZ_CP101728:c124868-124670 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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